Friday, May 31, 2013

Safe Kids Week: Make protecting your head a Healthy Choice ...

May 30 2013

GNWT_HSS_Choose_CMYK2

YELLOWKNIFE (May 30, 2013) ? Safe Kids Week is May 27 to June 3 in the Northwest Territories (NWT). The Government of the Northwest Territories (GNWT) is marking the Week by encouraging NWT residents to show that they have the helmet habit and post a video or picture of themselves wearing a properly fitting helmet online.

?We all know that helmets can save lives and reduce the severity of head injuries,? said Minister of Health and Social Services Tom Beaulieu, who stressed that it is important for parents, teachers, and coaches to make the prevention of brain injuries, such as concussions, a priority.? ?We have to ensure our children and young people are wearing their helmets when they are bicycling, skateboarding or engaged in other recreational activities.?

Helmet use in organized sports is already saving lives and preventing serious injuries says Municipal and Community Affairs Minister Robert C. McLeod, ?In our school and recreation programs across the NWT, young people are wearing their helmets to avoid potential head injuries,? he said. ?It?s important to bring that same good habit to the recreation activities both children and adults participate in.?

A concussion is a brain injury that affects the way a person thinks and remembers and can cause a variety of symptoms that affect health and behaviour. Until August 31, 2013, the GNWT is encouraging NWT residents to post a video or picture of themselves wearing a properly fitting helmet on Twitter using the hashtag #gotthehelmethabit to show that they have the helmet habit. Residents who email commcoordinator@gov.nt.ca with the time and date of their tweet will be entered in a draw to receive one of three GoPro HERO3: Black Edition helmet cameras. Names will be drawn in September.

Safe Kids Week is an initiative of Parachute, Canada?s injury prevention leader. Visit the Parachute website for more information and resources related to Safe Kids Week 2013.

The Healthy Choices Framework is the GNWT?s initiative to encourage NWT residents to make the right choices to protect their health, safety and wellbeing. The prevention of injuries is one of the pillars of the Framework intended to help meet the priority of the 17th Legislative Assembly to ensure a fair and sustainable health care system by investing in prevention, education and awareness. Visit www.choosenwt.com for more information on the Healthy Choices Framework.

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For further information:

Damien Healy
Manager of Communications
Department of Health and Social Services
(867) 920-8927
damien_healy@gov.nt.ca

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Earl Blacklock
Manager Public Affairs and Communications
Department of Transportation
(867) 445-3494
earl_blacklock@gov.nt.ca

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Source: http://news.exec.gov.nt.ca/safe-kids-week-make-protecting-your-head-a-healthy-choice/

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Brooke Shields Turns 48! Look Back at Her '80s Fashion

From puffy sleeves to high-waisted denim, the fashion trends of the '80s definitely seemed cool at the time. But now? Not so much. In fact, when we look back at photos of us in the '80s (in all their hairspray-soaked glory), we sometimes wish we could destroy the evidence. But that's not such an easy task for people who were mega-stars during the decade!

Source: http://www.ivillage.com/brooke-shields-awesome-80s-fashions/1-a-537613?dst=iv%3AiVillage%3Abrooke-shields-awesome-80s-fashions-537613

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NVIDIA Shield drops by the FCC, gets ready to fill pre-orders

NVIDIA Shield drops by the FCC, gets ready to fill preorders

Eager to get your mitts on NVIDIA's first Tegra 4 device? Cast your jealous eyes upon the federal government -- they've already got one. NVIDIA's Shield gaming handheld dropped by the FCC to get its label approved, betraying its original code name, Project Thor, in the processes. Hardly a surprise to see the device passing federal muster, of course, as it's slated for release at the end of next month. Unfortunately, the filings don't reveal any hidden goodies (that is, no cellular radio), just a standard WiFi antenna. Still, if label location drawings and test reports are your thing, check out the FCC link below.

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Source: FCC

Source: http://www.engadget.com/2013/05/30/nvidia-shield-drops-by-the-fcc-gets-ready-to-fill-pre-orders/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Advice on short sale process. (we are buyers) - Zillow Real Estate ...

Hi there. ?I feel your pain. ?And like so many buyers who are purchasing a short-sale, unfortunately there is nothing "short" about it. ?I had a foreclosure take 8 MONTHS due to a roof replacement, open pool permit that had to be dealt with, and they claimed prior termite damage that had to be repaired. ?And that wasnt even a SHORT-SALE!! ?It was certainly the longest deal I've ever had! ?But we got it done eventually.

In some cases, the HOA will negotiate a portion of their fees as well as some interest and potentially a portion of attorneys' fees. ?This part is a case by case depending on how much is owed and over what period of time.

Hope that helps somewhat? ?Good luck to you. ?Shayla Twit, Sarasota FL Realtor

Source: http://www.zillow.com/advice-thread/Advice-on-short-sale-process-we-are-buyers/494603/

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What Approach Could You Anticipate From A Huntington Beach ...

Huntington Beach is an extremely in demand city found in Orange County, Southern California. It is so prominent that numerous people make the step to stay there, and it has a human population of nearly 200,000 as of 2011. The ocean city is well visited and known for its huge section of sandy shore and also great beach lifestyle. The location is also great for scuba diving due to its terrific water and other shore attractions.

A number of health and fitness clubs and gymnasiums have already been constructed and managed in Huntington Beach for fitness and wellness needs of the homeowners and also travelers. You can actually select your Huntington Beach personal trainer to assist and allow you to be strong and attain your desired beach body. Undoubtedly, all people would like to enjoy the ocean more with a healthier and toned physique. Having the ability to flaunt your figure while swimming, diving, etc. is among the greatest ideas to love the seashore.

Conduct Of The Huntington Beach Personal Trainer

The attitudes of the personal trainer affects his / her career and service to his or her valued clients. His / her behaviour will also be reflected to their customers and would certainly influence the outcome of their training. Listed here are the traits that you could expect from the Huntington Beach personal trainer. Those are also the points that would assist you in your goal of a experiencing healthier lifestyle and a stronger physique.

* He or she must be results-oriented and well-motivated.

Expect a Huntington Beach personal trainer to be results-oriented. Naturally, she or he would really like you to lose a certain amount of pounds as well as body weight to obtain your ideal body. She or he expects you to become bodily toned just like her or him. She or he is driven by the hope to see outcomes on your fitness and health.

* He or she have to be focused and serious to assist you.

The fitness instructor must be devoted to her or his job so that you, the customer, will be centered as well to work out and also to achieve your goal. He or she needs to be focused and determined in assisting you.

* Expect that she or he is going to push you to your limits

As a knowledgeable instructor and somebody who is serious to assist you, she or he will press you hard to your limits in your workouts as well as ability. He or she knows the capacity of your body and are aware of when you can still do more.

* He would be helpful and respectful of your own personal built and limit.

A Huntington Beach personal trainer will certainly support you in your exercise while keeping in mind your overall health, physical fitness, and security. He / she is going to push you to your limits also at the same time should be mindful of your own personal ability, intensity, and condition.

Other Traits Of A Huntington Beach Personal Trainer

You may as well foresee a Huntington Beach personal trainer to possess these following attributes:

- He / she would be an expert fitness instructor and would have performed services with lots of other individuals, such as movie stars and personalities, with excellent outcomes.

- She or he would be properly educated and knowledgeable when it comes to fitness and health.

Getting back in good shape with the help of personal trainer Huntington Beach not only improves your physique but also your overall health as well. The rewards which an individual can get from Huntington Beach personal trainer are endless.

Source: http://hotarticledepot.com/what-approach-could-you-anticipate-from-a-huntington-beach-personal-trainer/

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Sunday, May 26, 2013

Kerry makes sub-Saharan Africa visit

ADDIS ABABA, Ethiopia (AP) ? Making his first official trip to sub-Saharan Africa, U.S. Secretary of State John Kerry on Saturday demanded that Nigeria respect human rights as it cracks down on Islamist extremists and pledged to work hard in the coming months to ease tensions between Sudan and South Sudan.

Kerry, attending the African Union's 50th anniversary, backed the Nigerian government's efforts to root out Boko Haram, an al-Qaida-linked radical sect. But he said there is no excuse for abuses by armed forces in Nigeria's long neglected north, where President Goodluck Jonathan has declared emergency rule.

"We defend the right completely of the government of Nigeria to defend itself and to fight back against terrorists," Kerry said. He added, however, that he has raised his concerns with Nigerian officials to insist on the military "adhering to the highest standards and not itself engaging in atrocities."

"One person's atrocities do not excuse another's," Kerry said. "Revenge is not the motive. It's good governance, it's ridding yourself of a terrorist organization so that you can establish a standard of law that people can respect."

Speaking to reporters alongside Ethiopian Prime Minister Hailemariam Desalegn, Kerry also blamed Sudan's government for much of the tension along its volatile border with South Sudan. He says residents in the contested areas of Blue Nile and South Kordofan don't want to be subjected to strict Islamist rules.

Both areas border the new nation of South Sudan, which gained independence in 2011 under an agreement that ended decades of civil war. Many residents are sympathetic to the South, and both areas have experienced regular violence in recent years.

"There are very significant border challenges, but they're bigger than that," Kerry said. "You have people who for a long time have felt that they want their secular governance and their identity respected."

"They don't want independence; they are not trying to break away from Sudan," he said. But he said the response from Sudan's government has been to "press on them through authoritarian means and violence an adherence to a standard that they simply don't want to accept with respect to Islamism."

"That's the fundamental clash," Kerry said.

He acknowledged, however, the North's concerns that the South is fueling rebels in the areas and said the U.S. would try to work with Ethiopia and other international partners to ease tensions. He said he'd soon appoint a new American envoy to both countries.

Kerry meets the foreign ministers of both Sudans later Saturday.

His meetings in Ethiopia's capital also include the U.N. and African Union chiefs and Egyptian President Mohammed Morsi.

Source: http://news.yahoo.com/kerry-makes-sub-saharan-africa-visit-065921088.html

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Saturday, May 25, 2013

Best iPhone and iPad apps for professional photographers: Take your shooting and your business to the next level!

Best iPhone and iPad apps for professional photographers

The iPhone and iPad apps every pro photographer needs to better and more easily manage photos, portfolios, payments, expense tracking, location mapping, contract signing, and more!

As a professional photographer, the iPhone and iPad can be excellent tools for your business. You are probably already aware that there's a lot of great apps out there focused on editing photos, but if we're being real, as a professional, you're not going to use them. However, there are many other great apps that can help compliment your business, and we've rounded up some of our favorites.

Shoot and Sell

If you're a photographer who offers prints and canvas to your clients, then Shoot and Sell is a fantastic app to show off how your clients' photos will look on the wall, even their wall. Designed by by the creators of Photographer's Wall Display Guides, Shoot & Sell is sure to help you generate more sales from each client.

See also:

FolioBook Photo Portfolio

FolioBook is your digital portfolio. Forget showing your website with Safari and use FolioBook to show off your work to potential clients. It lets you create a custom branded home page and as many galleries you'd like with up to 200 images per gallery. You can also create slideshows with transitions and music. The amount of customization that FolioBook allows is incredible and really lets you create a portfolio that reflects you and your brand.

Square

As the owner of a small business, utilizing a point of sale system like Square will simplify your life and impress your clients. People don't like carrying around checkbooks and cash, so accepting credit cards is a vital aspect of any business, and Square is a great option that will keep your costs down and bottom line up.

See also:

Easy Release - Model Release App

If you're a portrait photographer, you likely have your clients sign model releases and other contracts. Easy Release is a great app that comes preinstalled with some great release forms. You can also edit them to be more tailored to your business or create your own from scratch. Each release can be branded with your business and you can email to your clients immediately after they sign them.

PDF Expert

If you prefer to stick with the contracts and release forms you've already created and formatted into PDFs, you can still go paperless with PDF Expert. You can easily keep all your forms organized, and since PDF Expert supports annotation, your clients can easily sign the forms as if they were printed out in front of them.

Rego

When it comes to portrait photography, location is key, and Rego will help you keep track of all your favorite spots. With each location you can add photos and make notes about the lighting and anything else you want to remember.

Things

Running a business requires a lot of various tasks, and with Photography in particular, each shoot is like an individual project each of which has a set of required tasks. Things for iPhone, iPad, and Mac, is a great trio of apps to keep you on track and organize your business. It's a bit pricey and isn't the prettiest of apps, but it works really well.

Trip Cubby

As a photographer, you are likely driving all over the place to different shoots, and since all those miles are tax-deductible, a solid mileage tracking app is a must. Trip Cubby is an awesome choice and makes this daunting task a lot less cumbersome and is designed with IRS compliance in mind.

Trip Cubby does not support the iPhone 5's larger screen, and this is normally a huge turn-off for me, but it's truly one of the best options out there.

Quickbooks Mobile

One of the most difficult parts of running a business is keeping track of the finances. If you use Quickbooks, then the iPhone and iPad versions are a must. Having the ability to stay on top of your business finances on the go is a great convenience.

Dropbox

To successfully run a photography business, you must keep a lot of paper work, including contracts, release forms, invoices, financial records, and of course photos. The last thing you need is for some freak accident to cause you to lose it all, and with Dropbox, you can rest assured that your files are forever safe. Many of the previously mentioned apps in this list include Dropbox integration which makes it one of the best cloud solutions out there.

Your favorite apps for professional photography?

So there you have it! iMore's best apps for professional photographers! Did we miss any other great apps? What apps do you use to compliment your photography business?

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/5ix12ya-vuU/story01.htm

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Cannes: Dern a leading man again in 'Nebraska'

CANNES, France (AP) ? For the aging, gruff patriarch of his father-son road trip "Nebraska," Alexander Payne tried to lure Gene Hackman out of retirement and considered the likes of Robert Duvall and Jack Nicholson. Bruce Dern calls them "the obvious guys."

"He said to me, 'I got an idea. Let's surprise them with you,'" Dern recalled of learning from Payne that he had the part. Payne, he says, continued: "'You haven't done this. You haven't done anything like this. Let's have fun. Let's knock their socks off.'"

Though the part, reticent and cantankerous, isn't the typical socks-knocking kind of stuff, Dern's unadorned portrait has been one of the most hailed performances at the Cannes Film Festival, where the black-and-white "Nebraska" premiered to warm reviews Thursday. For Dern, whose days as a leading man were largely in the 1970s, working with Payne on "Nebraska" was deeply meaningful.

"All during your career, you look for a certain kind of security from the people you're working with, people that believe you're talented, that you can do what you can do," says the 76-year-old Dern, who was nominated for an Oscar for his performance in 1978's "Coming Home." ''I've been overrated sometimes and I've been underrated, probably more than I've been overrated."

Dern is an eager storyteller, and during an interview Friday, his conversation took detour upon detour, ranging from the directions of Alfred Hitchcock to how best to cheat at boarding school. His co-star in "Nebraska," the former "Saturday Night Live" player Will Forte, calls him, with understatement, "a bit of a talker."

In the film, Dern stars as Woody Grant, a retired, alcoholic veteran showing signs of senility. When he receives a mass mailing promising him a $1 million award, he sets out down the road from his Montana home to collect it in person in Nebraska. His son (Forte) placates him by driving him, including a stop his father's old hometown: "The guy needs something to live for," says the son.

It's a sweet but unsentimental tale of a son giving his father a sense of decency late in life. It will be released in November by Paramount Pictures amid the fall award season.

Dern calls Woody "a monument to the people like that, that still exist in this country ? a guy that's not going to leave, that's not going to get out." Dern risked, he says, "trying not to act."

"I said: 'I'll give you whatever you want. I won't give you what other directors want, because it's sparse,'" says Dern. "It's not a career-making role. I never smile. I never laugh. He never really gets angry except once. But there's no self-pity with Woody."

This is the second time a Dern has starred in a film by Payne. His 1996 feature debut, the abortion debate satire "Citizen Ruth," starred Laura Dern, Bruce's daughter. The actress lobbied Payne to cast her father.

"Both Derns will do anything you ask them to do," Payne told reporters. The director said he was as much drawn to Dern by his talent as by "who the man is."

"I like actors who can be ornery but heartbreaking at the same time," Payne said.

Dern, an avid lifetime runner, compared Payne's interest to him as coming on the 24th mile to the marathon of his career.

"I'll love him forever for that, for seeing in me that I could pull this off," Dern says of Payne. "He's different folks."

When Forte, early in the production, told Dern that he was having trouble adjusting to dramatic acting and establishing their relationship, Dern gave him some advice.

"I put my hand on his arm and I said, 'Just look at me every time in the movie and realize you may be working with a guy who's never going to make another movie,'" Dern says. "He got big tears in his eyes and said, 'Are you serious?' I said, 'No, it's all bull----. But you don't know that and I don't know that because if this fails, I'm done. They'll never let me play another lead in a movie.'"

The two spent weeks together in the close confines of a Subaru, says Forte: "I could just listen to him forever. He has the best stories. We became very close."

"I've been in some pretty good movies," says Dern. "This is the best movie I've been in. I hope it's as good a work as I've done."

___

Follow AP Entertainment Writer Jake Coyle on Twitter at: http://twitter.com/jake_coyle

Source: http://news.yahoo.com/cannes-dern-leading-man-again-nebraska-195112373.html

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Graduates in tornado-raked Okla. town vow to stay

Cheyenne Neuenschwander, 15, from Joplin, Mo., carries trash to the curb as she helps sort through her grandparent's tornado-ravaged home Saturday, May 25, 2013, in Moore, Okla. Cleanup continues after a huge tornado roared through the Oklahoma City suburb Monday, flattening a wide swath of homes and businesses. (AP Photo/Charlie Riedel)

Cheyenne Neuenschwander, 15, from Joplin, Mo., carries trash to the curb as she helps sort through her grandparent's tornado-ravaged home Saturday, May 25, 2013, in Moore, Okla. Cleanup continues after a huge tornado roared through the Oklahoma City suburb Monday, flattening a wide swath of homes and businesses. (AP Photo/Charlie Riedel)

(AP) ? Seven tornadoes have swept through their town since they were born, but as new graduates donned caps and gowns to say goodbye to their high schools Saturday, they vowed they wouldn't say goodbye to Moore.

"I wouldn't want to be in any other place. It's our roots. Tornadoes are a part of life here," said 18-year-old Brooke Potter, whose current college aspirations take her to two neighboring towns.

Saturday's graduations for Westmoore, Southmoore and Moore high schools are another step toward normalcy for this Oklahoma City suburb ravaged by an extremely strong tornado. Monday's twister killed 24, including seven children at Plaza Towers Elementary School.

"I want to end up back here," Madison Dobbs, 18, said. "I've been here my whole life and can't picture myself anywhere else. Tornadoes happen anywhere."

While that's true, few other places have the amount and severity of tornadoes like Oklahoma ? and no other place has had a tornado like Moore. The Storm Prediction Center in Norman says the Oklahoma City area has been struck by more tornadoes than any other U.S. city, citing records that date to 1893.

When the current graduating class was in second grade, Moore experienced an EF4 tornado with winds approaching 200 mph. And three months before they started pre-kindergarten, a twister with the highest winds on record ? 302 mph ? sliced through their town.

"Crazy storms happen, The goods outweigh the bads," said Potter, who wants to attend Oklahoma City Community College, and then transfer to the University of Oklahoma in neighboring Norman.

With graduates wearing red or black caps and gowns, Westmoore was the first of three schools to hold commencement ceremonies Saturday at the Cox Convention Center in Oklahoma City.

A teacher in the district said despite being big enough to have three high schools, the 56,000-strong community is still tightly knit.

"This is such a big district, but this is a small town," said Tammy Glasgow, a second-grade teacher at Briarwood Elementary, which was also destroyed but didn't have any deaths. "When you see somebody in the street, it's not a 'hi' and a handshake, it's a hug."

Some students lost everything in the violent storm. Southmoore senior Callie Dosher, 18, said she sifted through the debris of her family's destroyed home in the past few days, looking to recover precious possessions ? her mom's two Bibles and the teddy bear Callie's granddad gave her shortly before he passed away.

But Dosher, too, wants to stay: "These people, I've grown up with them. I have all my friends here," she said.

Miranda Mann, an 18-year-old Southmoore grad whose family also lost their home, couldn't recognize her own neighborhood because of the heavy damage. Yet they have vowed to rebuild on the same ground.

"We loved the house we were in," she said. "But we get to make new memories in the new house."

Westmoore Senior Alex Davis, 18, will attend University of Oklahoma after graduation partly so he can stay close to friends and family.

"It speaks to how the community's banded together," he said. "We're not going to let a natural disaster beat us."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-05-25-US-Oklahoma-Tornado-Graduation/id-117d099171034482a4c4b492517c920b

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Friday, May 24, 2013

HTC needs to seriously consider making a Google supported version of One

Google announced a special version of Samsung Galaxy S4 with their version of Android and support at I/O 2013.

Since then, a lot of us have wished for a similar version of HTC One. I am in this group. I love the design and build quality of the HTC One. But I would not touch the current model because of the customizations HTC likes to call Sense (Also BlinkFeed).

HTC has officially denied that they are making a Google supported version of One but the rumors are simply not dying. Industry analysts are in fact quite sure that a version is coming. Pretty soon in fact. As HTC has resolved the problems with the production and they should be perfectly capable of handling both the variants in enough numbers.

In fact, I would love Google to launch a similar version of all flagship devices launched by close partners. Sony Xperia Z should get a similar Google supported model. A lot of people are realizing the benefits of buying a Nexus devices? A Google supported variant of all major flagship models would only boost the concept behind the Nexus devices. And maybe these manufacturers would realize that customizing Android to insane levels might in fact be hurting them. Especially smaller players like HTC. Samsung on the other hand is doing fantastically well around the world.

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This entry was posted in News and tagged HTC, HTC One on by Sushubh Mittal.

Source: http://feedproxy.google.com/~r/TechWhackBlog/~3/Iw4NLAj3qkk/

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Check Out Jennifer Aniston As A Stripper! (VIDEO)

Check Out Jennifer Aniston As A Stripper! (VIDEO)

Jennifer Aniston panties and bra picsJennifer Aniston shows a very different side of herself in the movie trailer for her latest film, “We’re the Millers”. The 44-year-old actress strips down to lacy bra and panties as she performs a strip tease to prove she is a stripper and not your average housewife. Jennifer Aniston stars in the movie opposite former ...

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Source: http://stupidcelebrities.net/2013/05/check-out-jennifer-aniston-as-a-stripper-video/

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Biophysicists measure mechanism that determines fate of living cells

May 23, 2013 ? A new tension gauge tether (TGT) laboratory method developed at the University of Illinois at Urbana-Champaign has broad applications for research into stem cells, cancer, infectious disease, and immunology.

Cells in the human body do not function in isolation. Living cells rely on communication with their environment -- neighboring cells and the surrounding matrix -- to activate a wide range of cellular functions, including reproduction of new cells, differentiation of stem cells into distinct cell types, cell adhesion, and migration of white blood cells to fight bodily infections. This cellular communication occurs on the molecular level and it is reciprocal: a cell receives cues from and also transmits function-activating cues to its neighbors.

The mechanics of this type of cellular interaction have been studied extensively: receptors extending through the cell membrane are activated when they form a bond to specific molecules. Now for the first time, University of Illinois biophysicists at the Center for the Physics of Living Cells and the Institute for Genomic Biology have measured the molecular force required to mechanically transmit function-regulating signals within a cell.

The new laboratory method, named the tension gauge tether (TGT) approach, developed by Taekjip Ha with postdoctoral researcher Xuefeng Wang, and reported in the May 24, 2013, issue of the journal Science, has made it possible to detect and measure the mechanics of the single-molecule interaction by which human cell receptors are activated. The researchers used integrin, a cell membrane receptor protein that is activated when it bonds to a ligand molecule.

In the TGT approach, Ha and Wang repurposed DNA strands, using them as tethers for ligand molecules, to test the tension required to activate cell adhesion through integrin. The integrin bonds to the tethered ligand, and adhesion is activated only if the DNA tether does not rupture.

Taking advantage of the geometric characteristics of DNA's double helix form, the researchers were able to tune the strands to rupture at discrete tension levels: by varying the attachment points along the DNA strands, the force required for rupture was either low (unzipping the helix), high (shearing the strands), or intermediary (combination of unzipping and shearing).

"If you went fishing and a fish broke your 30-lb fishing line but not the 40-lb one, you would know that its strength was in the range of 30?-40 pounds," explained Wang. "Here we applied the same strategy to measure the molecular tension applied by cells (the fish). Mammalian cells apply a force to activate cell membrane proteins called integrins which mediate cell adhesion. We immobilized ligand molecules (the bait) on a surface through molecular tethers (the fishing line) with defined tension tolerances, tunable from 10 pico Newton (pN) to 60 pN). After integrin-ligand binding, cells apply a force on the bonds, and we compare this force to the molecular tether strength by observing cell adhesion status."

Since single-molecule interactions are difficult to monitor, the researchers observed the receptor-regulated cellular function, to gauge whether the integrin was activated. Ha and Wang discovered that integrin experiences a well-defined "quantum of force," about 40 pico-Newton (pN), to activate cell's adhesion to a surface.

"We observed that mammalian cells adhere on the culture surface with 43 pN tension tolerance of ligands, but not on 33 pN surface. Therefore we deduced that single molecular tension is around 40 pN on integrin cell-membrane receptors during cell adhesion," Wang added.

"This is a very exciting result," commented Ha, an Edward William and Jane Marr Gutgsell Endowed Professor at Illinois. "With the ability to define the single molecular forces required to make living cells behave as desired, we may be one step closer to a remedy for certain hard-to-cure diseases. We know that the behavior of cancer cells and stem cells can be controlled by how stiff or soft their environments are. Understanding and manipulating molecular conversation through defined forces has huge implications for the development of future medical interventions. We expect the TGT approach will have broad applications in laboratory studies of cell differentiation, cancer metastasis, as well as immunology and infectious disease."

This research was funded by the National Science Foundation through the Physics Frontiers Center Program (0822613). In addition to his appointment at the University of Illinois, Taekjip Ha is an investigator with the Howard Hughes Medical Institute.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/biochemistry/~3/23f8HDeLow4/130523143735.htm

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Thursday, May 23, 2013

Dot Earth Blog: Terrible Tornadoes in a Changing Climate

As I explained earlier this week, questions related to any impact of human-driven global warming on tornadoes, while important, have almost no bearing on the challenge of reducing human vulnerability to these killer storms. The focus on the ground in Oklahoma, of course, will for years to come be on recovery and rebuilding ? hopefully with more attention across the region to developing policies and practices that cut losses the next time. (With this in mind, please read John Schwartz?s great feature, ?Why No Safe Room to Run To? Cost and Plains Culture.?)

The vulnerability is almost entirely the result of fast-paced, cost-cutting development patterns in tornado hot zones, and even if there were a greenhouse-tornado connection, actions that constrain greenhouse-gas emissions, while wise in the long run, would not have a substantial influence on climate patterns for decades because of inertia in the climate system.

Some climate scientists see compelling arguments for accumulating heat and added water vapor fueling the kinds of turbulent storms that spawn tornadoes. But a half century of observations in the United States show no change in tornado frequency and a declining frequency of strong tornadoes. [Update?| The meteorological conditions that shaped events in recent days are?nicely explored by Henry Fountain of The Times.]

Does any of this mean global warming is not a serious problem? No.

It just means assertions that all weird bad weather is, in essence, our fault are not grounded in science and, as a result, end up empowering those whose prime interest appears to to be sustaining the fossil fuel era as long as possible. I was glad to see the green blog Grist acknowledge as much.

On Tuesday, I sent the following query to a range of climate scientists and other researchers focused on extreme weather and climate change:

The climate community did a great service to the country in 2006 in putting out a joint statement [from some leading researchers] on the enormous human vulnerability in coastal zones to hurricanes ? setting aside questions about the role of greenhouse-driven warming in changing hurricane patterns?.

In this 2011 post I proposed that climate/weather/tornado experts do a similar statement for Tornado Alley.

I?d love to see a similar statement now from meteorologists, climatologists and other specialists studying trends in tornado zones. Any takers?

Before you dive in to the resulting discussion, it?s worth reading Andrew Freedman?s helpful Climate Central piece, ?Making Sense of the Moore Tornado in a Climate Context,? and a Daily Beast post by Josh Dzieza. The National Oceanic and Atmospheric Administration has posted a helpful new fact sheet, ?Tornadoes, Climate Variability, and Climate Change.? [Update|?Robert Kunzig of National Geographic has written?an excellent overview of tornadoes and greenhouse warming.]

Read on for the conversation on tornadoes and global warming, with some e-mail shorthand fixed.

First, I?m posting the comments that were focused on policy, then those focused on the details of the science:

Roger Pielke, Jr., professor of environmental studies, the University of Colorado:

People love to debate climate change, but I suspect that the community?s efforts are far better placed focusing attention on warnings and response. That is what will save lives and continue the really excellent job that has been done by NOAA and the National Weather Service. I?d much rather see a community statement highlighting the importance of NOAA/NWS funding!

There will always be fringe voices on all sides of the climate debate. With the basic facts related to tornadoes so widely appreciated (unlike perhaps drought, floods, hurricanes), I think that those who see climate change in every breeze are not particularly problematic or worthy of attention.

Here are some of those basic facts:

1. No long-term increase in tornadoes, especially the strongest ones.
2. A long-term decline in loss of life (the past year saw a record low total for more than a century).
3. No long-term increase in losses, hint of a decrease.
4. To date 2013 has been remarkably inactive.
5. The Moore tornado may have been the strongest one this year, bad luck had it track through a populated area (Bill Hooke brilliantly explained the issue here).
6. That said, climatology shows that Moore sits at the center of a statistical bullseye for tornado strikes for May 20th.

Kerry Emanuel, professor of atmospheric science, Massachusetts Institute of Technology (a signer of the 2006 statement):

I see the political problem with tornadoes as quite different from the hurricane problem we wrote about some years ago. To my knowledge, there are no massive subsidies to build in tornado regions, nor is insurance premium price fixing a big problem. Also, federal flood insurance is largely irrelevant to this problem. About the only thing in common is federal disaster relief, but it is hard to believe that people only build houses in huge swaths of tornado-susceptible territory because they believe they will be bailed out.

As you mention in your blog, the issues here revolve around such practical measures as safe rooms, and the role of government in mandating or subsidizing them. Perhaps one positive outcome of the latest horror story is that safe rooms in public buildings such as schools and hospitals will be mandated, given that they are apparently not all that expensive.

In my view, the data on tornadoes is so poor that it is difficult to say anything at all about observed trends, and the theoretical understanding of the relationship between severe thunderstorms in general (including hail storms) and climate is virtually non-existent. I regard this as a research failure of my profession and expect there will be a great deal more work on this in the near future. What little exists on the subject (e.g. the Trapp et al. paper from a few years ago) suggests that warming will increase the incidence of environments conducive to severe thunderstorms in the U.S. But this counts on climate models to get these factors right, and it may be premature to put much confidence in that.

Daniel Sutter, a professor of economics (focused on tornadoes), Troy University, offered the following thought after citing the Dot Earth comments of Kevin Simmons, his co-author on a recent book on tornadoes and society:

I would just add that the high cost per life saved through safe rooms which Kevin and I find in our research really indicates that tornado safety is about reducing and not eliminating risk. Safe rooms provide essentially absolute protection, but are expensive enough that many would likely judge them too expensive. We need to focus on ways to reasonably reduce risk. For instance, have engineers inspect schools and make sure the safest areas are indeed being used for shelter, or to see if there are relatively inexpensive designs that could strengthen interior hallways some.

I hate to say anything before I know for sure what the final story is from the Plaza Heights school, but the two schools yesterday appear to have provided pretty decent protection, especially since many homes around Briarwood school looked totally destroyed. Wind engineers have developed safe room designs which are great and engineering marvels, but we probably need designs that provide a good measure of safety at a portion of the price.

Also with regard to your previous post about flimsy homes, consider the contrast between how cars and houses are marketed. Cars are sold under brand names, and we have a dual system of federal regulation of designs for safety and auto makers designing cars that are safer than federal regulations require, with certification by the Insurance Institute for Highway Safety. Houses are mainly sold without brand names (I couldn?t tell you who built the house I own here in Alabama) with safety assurances coming through building codes. Many times we see that homes perform poorly in tornadoes or hurricanes, while during a commercial break on the Weather Channel last night there was a car ad touting the model?s crash test rating from the IIHS. If houses are indeed flimsy, there is probably a systematic reason for this.

Thomas Knutson, a research meteorologist at the Geophysical Fluid Dynamics Laboratory of the National Oceanic and Atmospheric Administration (a signer of the 2006 hurricane statement):

While the debate/discussion about possible climate change impacts (or not) on tornadoes is interesting, I thought that the helpful aspect of Kerry?s approach in 2006 was to set aside the climate change debate aspect and instead focus on something we could all agree on.

For example, in the tornado case, if some group of people who otherwise disagree about the climate change issue, could at least agree that it makes sense to have better physical designs of structures, have available shelters in mobile home parks, etc. in an effort to save live, would this be a useful statement to make? Maybe Bill [Hooke], Harold [Brooks] or others would have a good list of recommendations that make sense regardless of whether the tornado climate is stationary or not.

William H. Hooke, associate executive eirector and senior policy fellow, American Meteorological Society:

This has been a terrific discussion and Tom Knutson is getting us to a good spot.

Two points could be made in any such statement:

1. Nature is essentially playing that kids? game of ?Battleship? with us. Population growth and urban sprawl have transformed much of Tornado Alley from a rural area to a target-rich environment, as I described in a post two years ago.

2. It?s not enough to improve warnings. Those getting the warnings need real options for action. Evacuation is risky. Shelter-in-place in tornado shelters (used once in a blue moon if at all) has the obvious downside that unless maintained, they become a haven for snakes, vermin, insects? generally unpleasant destinations. Some owners of tornado shelters have had to lock them up because they?ve become ?attractive nuisances? in the legal jargon, serving as venues for pot parties, etc. Better option is the ?safe room? interior to the house that is used daily or frequently for other purposes.

Here?s the science-focused part of the discussion:

Kevin Trenberth, distinguished senior scientist, National Center for Atmospheric Research:

You do everyone a disservice to discount climate change the way you do. Of course tornadoes are very much a weather phenomenon. They come from certain thunderstorms, usually super-cell thunderstorms that are in a wind shear environment that promotes rotation. That environment is most common in spring across the US: when the storm track is just the right distance from the Gulf and other sources of moisture.

The main climate change connection is via the basic instability of the low level air that creates the convection and thunderstorms in the first place. Warmer and moister conditions are the key for unstable air. The oceans are warmer because of climate change.

The climate change effect is probably only a 5 to 10% effect in terms of the instability and subsequent rainfall, but it translates into up to a 33% effect in terms of damage. (It is highly nonlinear, for 10% it is 1.1 to the power of 3 = 1.33). So there is a chain of events and climate change mainly affects the first link: the basic buoyancy of the air is increased. Whether that translates into a super-cell storm and one with a tornado is largely chance weather.

Martin P. Hoerling, National Oceanic and Atmospheric Administration:

I am unaware, but interested to learn more, about the scientific evidence that supports the statement in Kevin?s e-mail. The context of the sentence is in regard to tornadoes, but perhaps the comment he makes pertains to something else?.it is unclear and confusing without the source reference:

Here is his statement he offers that I?m especially curious about:

?The climate change effect is probably only a 5 to 10% effect in terms of the instability and subsequent rainfall, but it translates into up to a 33% effect in terms of damage. (It is highly nonlinear, for 10% it is 1.1 to the power of 3 = 1.33).?

There are some additional points that Kevin raises which are interesting, but incomplete. He writes:

?The main climate change connection is via the basic instability of the low level air that creates the convection and thunderstorms in the first place. Warmer and moister conditions are the key for unstable air. The oceans are warmer because of climate change. ?

The environment conducive for severe tornadic storms requires many ingredients, not least of which is the vertical shear of the wind in the storms environment, especially in the region near the base of the cloud (Harold can give the specifics). A further potential climate change connection, which Kevin overlooks, is the impact of a warmer world on the strength of the prevailing winds, and their increase in strength with height. Indications from peer review (e.g., Trapp et la. 2007, PNAS) is that changes in shear will act in opposition to changes in stability, making an overall assessment of possible impacts of climate change on severe convection difficult at this time.

It should be obvious that if stability and moisture were the main connections to severe convection, then summer (rather than spring) would be the season of most severe weather over the U.S. The dynamical ingredients associated with wind shear, and the triggers for releasing the latent and sensible instabilities, are critical to the problem.

Trenberth, replying to Hoerling:

With respect to climate change, one has to ask what are the influences on the atmosphere either from changes in atmospheric composition etc. or the places where memory occurs of the accumulated effects: mainly the oceans. ?Yes wind shear, and weather systems etc. are important but they are largely internal to the atmosphere and dependent on the synoptic situation.

Even models that suggest a change in overall mean winds or wind shear at some point in the future may not be particularly relevant with respect to the weather and the synoptic situations. And those models don?t exactly simulate today?s conditions well anyway. We will still have spring. It may come a bit earlier in general (changing the timing of the tornado season) but I have no doubt it will come.

Tornadoes require thunderstorms and wind shear, which occur in spring, not summer. ?Indeed the location of the storm track relative to the Gulf and sources of moisture is pretty critical. If it is too far north then there is no link (last year), or too far south then the wind shear is lost. ?You should recognize the unique situation in the U.S. where more tornadoes occur than anywhere else in the world, and the geography, Rockies, Gulf etc. plus seasons and weather all come into play. ?It is trite to say ?what about summer!?

?There are many papers detailing changes in water vapor and precipitation (although the literature is confusing).? Here is an example that tries to cut through some confusion.

Trenberth, K. E., 2011: Changes in precipitation with climate change.?Climate Research,?47, 123-138, doi:10.3354/cr00953.?[PDF]

I have then presumed that an increase in intensity and a change in wind speed goes up as wind speed cubed with respect to power dissipation and damage potential.

Martin Hoerling, replying to Trenberth:

To the point of Trapp et al., they discuss more than the effect of changes in thermodynamic stability. To be sure, increased thermodynamic instability, increased moisture content in the atmosphere (2 factors that Kevin called out), and increased vertical wind shear within 5 kilometers above the ground create an environment more favorable for a tornado outbreak. In particular, tornadoes are more likely to occur when both low stability (reflected in high values of ?convective available potential energy? or ?CAPE?), and high shear are present.

Secondarily, the presence of an elevated mixed layer (reflected in moderate values of ?convective inhibition? or ?CIN?) can delay the onset of storms, such that when they occur, they do so more explosively and in the form of more long-lived, isolated supercells, which can spawn tornadoes. Trapp et al. suggest that the number of days during which meteorological conditions are favorable for severe storms may increase during latter decades of the 21st century, primarily due to increased instability, though they indicate that the projected decreases in vertical wind shear may oppose thermodynamic destabilization..

Harold Brooks, National Severe Storms Laboratory, Norman, Okla.:

I?m not sure what we?ll be able to come with, but some basic points.

1. Interannual variability is incredibly large. It will be very difficult to detect long-trend trends. In the last 3 years, we?ve set records for the most F1+ tornadoes (back to 1954) in a 12 consecutive month period and for the fewest F1+ tornadoes. I think there?s evidence to suggest that we have seen an increase in the variability of occurrence in the US.

2. Probability of occurrence is mostly driven by wind shear and intensity is almost completely independent of the thermodynamics. The observations are clear on that. As a result, expected changes in occurrence and intensity would be driven by wind shear changes. NOAA is doing some new work on this, but Brian Soden indicated to me that ~2/3 of the CMIP runs showed an increase in CAPE and a decrease in shear over the US.

3. There are more F1+ tornadoes in warm winter months and fewer in warm summer months. Given that there are more in the mean in the summer than winter, overall, if we take the warmest 10 Januarys, 10 Februarys, etc. back to 1954 and count the tornadoes in them and compare it to the coolest 10 Januarys, 10 Februarys, etc., there are ~20% fewer tornadoes in the collection of warm months.

11:41 a.m. | James B. Elsner, an atmospheric scientist at Florida State University studying extreme storms, sent this thought by e-mail:

As with hurricanes, I think frequency needs to be separated from intensity.

Climate change increases the available energy for tornadoes through a warmer and moister atmosphere. Wind shear decreases in the global mean, but this might be irrelevant locally when the jet stream dives southward like it did last weekend across the Plains.

I believe there is evidence that the strongest tornadoes are getting stronger. They are certainly getting longer and wider.

I was out chasing this weekend in the Plains with my graduate students and the interesting thing was the lack of a widespread outbreak in favor of a few mighty ones. Shear was amazing.

Source: http://dotearth.blogs.nytimes.com/2013/05/22/seeking-clarity-on-terrible-tornadoes-in-a-changing-climate/?partner=rss&emc=rss

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Senate panel OKs tax-welfare benefits for newly legal immigrants ...

amnesty_01_webThe Senate Judiciary Committee voted Monday to allow illegal immigrants who get legal status to begin collecting tax-welfare payments, as the panel spent a fourth day working through amendments to the massive immigration bill and party-line splits began to emerge.

In one major change, the committee voted 17-1 to make a third drunken-driving conviction a deportable offense for the newly legalized immigrants if at least one of those offenses occurs after they are approved for legal status.

But immigrant-rights groups called that a rollback of due-process rights for the immigrants and said a drunken-driving incident shouldn?t cost someone a chance at citizenship.

?We cannot and will not support hard-line proposals that take away discretion and limit an individual?s ability to pursue the pathway to citizenship,? said Paromita Shah, associate director of the National Lawyers Guild?s National Immigration Project.

Overall, the committee continued to maintain the delicate balance struck by the ?Gang of Eight? senators who negotiated the 867-page bill: Quick legal status for illegal immigrants, but delaying citizenship rights until after the administration spends more money on border security, puts in place a new electronic verification system to check workers? status, and enacts an entry-exit system to check visas at airports and seaports.

In previous days? action, two Republican members of the Gang of Eight ? Sens. Lindsey Graham of South Carolina and Jeff Flake of Arizona ? joined with Democrats to block a series of GOP amendments to stiffen the bill?s security.

But on Monday, the two Republicans sided with their party colleagues on key questions on giving illegal immigrants public benefits.

The 10 Democrats on the committee still outnumber the newly unified Republicans, but the votes signaled tough fights ahead on the Senate floor.

In one vote, Sen. Jeff Sessions, Alabama Republican, tried to prevent anyone but citizens and green-card holders from being able to claim the Earned Income Tax Credit, which uses the tax code to transfer money to the poor.

But Sen. Charles E. Schumer, New York Democrat, said that would deny the tax credit not only to legalized immigrants but also refugees, asylum-seekers and other legal workers.

And Sen. Mazie K. Hirono, Hawaii Democrat, said denying the tax credit to legalized immigrants would hurt their children, many of whom are U.S. citizens.

The committee avoided what likely would have been a bitter fight over guns and whether those on the government?s terrorist watch list should be allowed to buy firearms when Sen. Sheldon Whitehouse, Rhode Island Democrat, withdrew his amendment.

?Evidently we think it?s OK for people on the terrorist watch list to buy a gun,? Mr. Whitehouse said.

He said he would try again later when the bill comes to the Senate floor.

Written by Stephen Dinan and published at Washington Times, May 20, 2013.

FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of environmental, political, human rights, economic, democracy, scientific, and social justice issues, etc. We believe this constitutes a ?fair use? of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U. S. C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes. For more information go to: http://www. law. cornell. edu/uscode/17/107. shtml

Source: http://www.federalobserver.com/2013/05/22/senate-panel-oks-tax-welfare-benefits-for-newly-legal-immigrants/

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Google cuts the cost of Apps for Business in India by ... - The Next Web

As part of an effort to help small and medium sized enterprises in India, Google today announced it would slash the cost of its Google Apps for Business suite in the country by almost half.

Citing the miniscule percentage of small businesses in the country that are online ? just 1 percent of 47 million -?Google has committed itself to offering its business services to the myriad of up-and-coming enterprises at a reduced price.

Access to the Google Apps for Business suite formerly cost INR 2700 (about $48.73) at an annual rate and INR 270 ($4.87) at a monthly rate, Indian businesses can now use the services for INR 1500 at an annual rate (about $27.07) or for INR 150 (about $2.70) at a monthly rate. The price drop marks a decrease of about 45 percent.

With the reduction in cost, millions of Indian businesses can now more easily access?web mail, calendars, cloud storage, and video chat, and other basic functions that are essential to running a business online in this day and age. Even though internet access isn?t widespread in some parts of India,

?By making Google Apps more affordable, we hope more small businesses in India will be able to access a business-ready package of communication and collaboration tools and reap the benefits of working in the cloud,? says Judy Chang, a representative for Google Apps for Business.

Considering the how the high cost of Microsoft Office often leads to counterfeits and piracy in rising Asian nations, an affordable Google Apps for Business suite might prove a preferable alternative for those in India who recognize the benefits of using legitimate software.

The move might seem a little counterintuitive to some observers, as last year Google announced it had formally ended?free access to Google Apps. By lowering the cost of the service in emerging economies, however, Google can provide invaluable assistance to emerging economies, while continuing to reap a sizable, if reduced, financial benefit.

Image credit via Shutterstock

Source: http://thenextweb.com/asia/2013/05/22/google-reaches-out-to-small-businesses-in-india-by-slashing-price-of-google-apps-for-business/

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Alabama Baseball Gets Blanked By No. 2 LSU In SEC Tournament

Alabama Generic

Hoover, Ala. ? In the second round of the 2013 SEC Baseball Tournament, the Alabama Crimson Tide suffered a 3-0 loss to the second-ranked and No. 2 seeded LSU Tigers on Wednesday afternoon from the Hoover Met. Following the loss, Alabama will play the No. 21 ranked Mississippi Rebels in an elimination-game on Thursday morning with first pitch scheduled for 9:30 p.m. CT from the Hoover Met.

?We tip our hat to LSU and Cody Glenn, he was outstanding? Alabama head coach Mitch Gaspard said. ?He changed speeds and moved the ball around. We couldn?t get any good swings off and they played clean. With the exception of the first inning, where I thought we were sloppy and they put good swings on him. Charley responded and I was really pleased with the way he settled in and was able to go the distance and save the bullpen.?

LSU (49-8) scored all their runs in the first inning, scoring three times on three hits against Alabama (33-25) starting pitcher Charley Sullivan. Sullivan (5-6) would go on to throw all eight innings, allowing three earned runs on eight hits with two walks and three strikeouts.

On the other side of the field, LSU?s starting pitcher Cody Glenn blanked the Tide for seven innings, allowing five hits with two strikeouts. En route to his seventh win of the season, Glenn (7-2) did not allow a runner to reach second base until the seventh inning, when the Tide had runners on first and second with two outs.

LSU relievers Nick Rumbelow and Chris Cotton threw two scoreless innings to finish the shutout. Cotton retired all three hitters he faced in the ninth to record his 13th save of the year.

Brett Booth had two of the Tide?s six hits and finished the day 2-for-4. Kenny Roberts, Georgie Salem, Kyle Overstreet and Chance Vincent all had singles for Bama.

Tigers? freshman shortstop Alex Bregman had three of the eight LSU hits, as he finished the day 3-for-4 with a run scored. Sean McMullen was 1-for-3 with a run scored and Mason Katz and Christian Ibarra were both 1-for-3 with an RBI.

LSU did all its scoring in the bottom of the first inning. After McMullen singled off the glove of UA third baseman Kenny Roberts, he advanced to third on a fielding error by Bama left fielder Andrew Miller. Mark Laird grounded out to short to allow McMullen to score the first run.

With the bases empty, Bregman doubled to the corner in left field and Katz walked to put runners on first and second. With the runners moving on the pitch, Raph Rhymes hit a slow roller back between home plate and the pitcher?s mound. Poor communication by Sullivan and Booth left home plate uncovered and Bregman scored from second as Sullivan threw out Rhymes at first. Katz scored the third run of the inning and the last run of the game on a single by Ibarra.

After the three-run first, LSU was limited to six base runners over the next seven innings. For Alabama, Glenn allowed six base runners through seven innings, and faced three batters over the minimum through his first six innings of work.

Alabama had a couple of late chances, getting a pair of runners on in the seventh and eighth innings. In the seventh, Austen Smith was hit by a pitch and Booth singled with two outs, but the threat ended when Miller grounded out to first. Off Rumbelow in the eighth, the Tide got a one out single by Roberts and Salem reached on an error. Overstreet flied out to left and Ben Moore grounded out to second, ending Alabama?s best scoring opportunity of the day.

The Crimson Tide will continue play in the SEC Tournament with the 9:30 a.m. CT game against No. 21 Mississippi on Thursday. Alabama is slated to start sophomore right-handed pitcher Spencer Turnbull (4-3, 3.61) and the Rebels will counter with freshman righty Jacob Wageuspack (0-1, 2.89).

Courtesy UA Media Relations

Source: http://whnt.com/2013/05/22/alabama-baseball-gets-blanked-by-no-2-lsu-in-sec-tournament/

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Wednesday, May 22, 2013

Visual search function: Where scene context happens in our brain

May 21, 2013 ? In a remote fishing community in Venezuela, a lone fisherman sits on a cliff overlooking the southern Caribbean Sea. This man -- the lookout -- is responsible for directing his comrades on the water, who are too close to their target to detect their next catch. Using abilities honed by years of scanning the water's surface, he can tell by shadows, ripples, and even the behavior of seabirds, where the fish are schooling, and what kind of fish they might be, without actually seeing the fish. This, in turn, changes where the boats go, and how the men fish.

Though a seemingly simple and intuitive strategy, the lookout's visual search function -- a process that takes mere seconds for the human brain -- is still something that a computer, despite technological advances, can't do as accurately.

"Behind what seems to be automatic is a lot of sophisticated machinery in our brain," said Miguel Eckstein, professor in UC Santa Barbara's Department of Psychological & Brain Sciences. "A great part of our brain is dedicated to vision."

Over the millennia of human evolution, our brains developed a pattern of search based largely on environmental cues and scene context. It's an ability that has not only helped us find food and avoid danger in humankind's earliest days, but continues to aid us today, in tasks as banal as driving to work, or shopping; or as specialized as reading X-rays.

Where this -- the search for objects using scene and other objects -- occurs in the brain is little understood, and is for the first time discussed in the paper, "Neural Representations of Contextual Guidance in Visual Search of Real-World Scenes," published recently in the Journal of Neuroscience.

The researchers flashed hundreds images of indoor and outdoor scenes before observers, and instructed them to search for certain objects that were consistent with those scenes. Half of the images, however, did not contain the target object. During the trials, the subjects were asked to indicate whether the target object was present in the scene.

The researchers were particularly interested in the images that did not contain the target. Another measure was taken to determine where subjects expected specific objects to be in target-absent scenes. Invariably, the subjects would indicate similar areas: If presented with a living room scene and told to look for a clock or a painting, they would indicate the wall; if shown a photo of a bathroom and told to indicate where to expect a hand soap or toothbrush, they would indicate the sink.

The searched object's contextual location in the scenes, according to the study, is represented in the area called the lateral occipital complex (LOC), a place that corresponds roughly to the lower back portion of the head, toward the side. This area, according to Eckstein, has the ability to account for other objects in the scene that often appear in close spatial proximity with the searched object -- something computers are only recently being taught to do.

"So, if you're looking for a computer mouse on a cluttered desk, a machine would be looking for things shaped like a mouse. It might find it, but it might see other objects of similar shape, and classify that as a mouse," Eckstein said. Computer vision systems might also not associate their target with specific locations or other objects. So, to a machine, the floor is just as likely a place for a mouse as a desk.

The LOC, on the other hand, would contain the information the brain needs to direct a person's attention and gaze first toward the most likely place that a mouse might be, such as on top of the desk, or near the keyboard. From there, other visual parts of the brain go to work, searching for particular characteristics, or determining the target's presence.

So strong is the scene context in biasing search, said Eckstein, that if another similar-looking object was placed in the location where the mouse is likely to be, and that scene briefly flashed before your eyes, you would likely -- erroneously -- interpret that object as the mouse.

While scene context information has been found highly active in the LOC, other visual areas of the brain are also influenced by context to certain degrees, including the interparietal sulcus, located near the top of the head; and the retrosplenial cortex, found in the brain's interior.

"Since contextual guidance is a critical strategy that allows humans to rapidly find objects in scenes, studying the brain areas involved in normal humans might help us to gain a better understanding of neural areas involved in those with visual search deficits, such as brain-damaged patients and the elderly," Eckstein said. "Also, a large component of becoming an expert searcher -- like radiologists or fishermen -- is exploiting contextual relationships to search. Thus, understanding the neural basis of contextual guidance might allow us to gain a better understanding about what brain areas are critical to gain search expertise."

Research on this study was also performed by visiting researcher and first author Tim Preston, Fei Guo, Koel Das, and Barry Giesbrecht, all from the Department of Psychological and Brain Sciences, and from the Institute for Collaborative Biotechnologies at UCSB.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/c_WEqd9rR88/130521105706.htm

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Bacterial spare parts filter antibiotic residue from groundwater

May 21, 2013 ? Researchers at University of Cincinnati have developed and tested a solar-powered nano filter that is able to remove harmful carcinogens and antibiotics from water sources -- lakes and rivers -- at a significantly higher rate than the currently used filtering technology made of activated carbon.

They report their results today at the 113th General Meeting of the American Society for Microbiology.

Vikram Kapoor, environmental engineering doctoral student, and David Wendell, assistant professor of environmental engineering, report on their development and testing of the new filter made of two bacterial proteins that was able to absorb 64 percent of antibiotics in surface waters vs. about 40 percent absorbed by the currently used filtering technology made of activated carbon. One of the more exciting aspects of this filter is the ability to reuse the antibiotics that are captured.

"The presence of antibiotics in surface waters is harmful in that it breeds resistant bacteria and kills helpful microorganisms, which can degrade aquatic environments and food chains. In other words, infectious agents like viruses and illness-causing bacteria become more numerous while the health of streams and lakes degrades," says Kapoor.

The newly developed nano filters, each much smaller in diameter than a human hair, could potentially have a big impact on both human health and on the health of the aquatic environment (since the presence of antibiotics in surface waters can also affect the endocrine systems of fish, birds and other wildlife).

The filter employs one of the very elements that enable drug-resistant bacteria to be so harmful, a protein pump called AcrB.

"These pumps are an amazing product of evolution. They are essentially selective garbage disposals for the bacteria. Our innovation was turning the disposal system around. So, instead of pumping out, we pump the compounds into the proteovesicles," says Kapoor

The operation of the new filtering technology is powered by direct sunlight vs. the energy-intensive needs for the operation of the standard activated carbon filter.

The filtering technology also allows for antibiotic recycling.

"After these new nano filters have absorbed antibiotics from surface waters, the filters could be extracted from the water and processed to release the drugs, allowing them to be reused. On the other hand, carbon filters are regenerated by heating to several hundred degrees, which burns off the antibiotics," says Kapoor.

The new protein filters are highly selective. Currently used activated carbon filters serve as "catch alls," filtering a wide variety of contaminants. That means that they become clogged more quickly with natural organic matter found in rivers and lakes.

"So far, our innovation promises to be an environmentally friendly means for extracting antibiotics from the surface waters that we all rely on. It also has potential to provide for cost-effective antibiotic recovery and reuse," says Kapoor.

The researchers have tested the solar-powered nano filter against activated carbon, the present treatment technology standard outside the lab, in water collected from the Little Miami River. Using only sunlight as the power source, they were able to selectively remove the antibiotics ampicillin and vancomycin, commonly used human and veterinary antibiotics, and the nucleic acid stain, ethidium bromide, which is a potent carcinogen to humans and aquatic animals.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/63s9OA1mO5c/130521194001.htm

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